GHK CU Copper Peptide

Price range: $40.00 through $55.00

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Description

GHK CU Copper Peptide

GHK-Cu, or Glycyl-L-Histidyl-L-Lysine Copper, is a naturally occurring tripeptide complexed with copper ions (Cu²⁺). It’s found in human plasma, saliva, and urine, with levels declining with age (from ~200 ng/mL at age 20 to ~80 ng/mL by age 60). Discovered in 1973 by Dr. Loren Pickart, it’s widely used in cosmetics and researched for regenerative and anti-aging effects.

Chemical Structure

Sequence: Gly-His-Lys (GHK) bound to Cu²⁺.
Molecular formula: C₁₄H₂₄N₆O₄Cu.
Key feature: The copper ion enhances bioavailability and bioactivity, allowing GHK-Cu to act as a signaling molecule.

Key Benefits and Research Evidence

GHK-Cu is popular in skincare (e.g., serums, creams) and has emerging therapeutic applications. Here’s a breakdown supported by studies:

Benefit	Mechanism	Evidence
Wound Healing & Skin Repair	Stimulates collagen, elastin, and glycosaminoglycan production; promotes angiogenesis (new blood vessels); reduces inflammation.	Rat studies (1988, Pickart): Accelerated healing of ischemic wounds by 40-60%.<br>- Human trials (2015, Pickart review): Improved diabetic ulcers and post-surgical scars.
Anti-Aging (Wrinkle Reduction)	Upregulates 4,000+ genes for tissue remodeling; downregulates inflammatory genes.	Clinical trial (2012, Leyden et al.): 12-week topical use reduced wrinkles by 31-55% vs. placebo (n=71 women).<br>- In vitro: Boosts fibroblast activity, mimicking youthful gene expression (2014, Pickart).
Hair Growth	Prolongs anagen (growth) phase; inhibits DHT-induced follicle miniaturization.	Mouse studies (2007): Increased follicle size and growth by 20-30%.<br>- Human anecdotal + small trials: Comparable to minoxidil in some users.
Anti-Inflammatory & Antioxidant	Modulates NF-κB pathway; scavenges free radicals; remodels extracellular matrix.	Lung fibrosis models (2014): Reduced inflammation markers by 50%.<br>- Copper’s role: Enhances SOD (superoxide dismutase) activity.
Other Potential	Neuroprotection, DNA repair, cancer metastasis inhibition (preclinical).	Alzheimer’s models (2010): Reduced tau protein aggregation.<br>- Metastasis studies (2012): Blocked invasive genes in lung cancer cells.

Sources: Peer-reviewed papers in Journal of Investigative Dermatology, BioMed Research International, and Pickart’s reviews (e.g., 2015 in Oxidative Medicine). PubMed has 100+ studies; search “GHK-Cu” for latest.

Usage and Products

Topical: 0.1-1% concentrations in serums (e.g., The Ordinary “Buffet + Copper Peptides,” NIOD Copper Amino Isolate). Apply 1-2x daily; blue color fades on skin.
Injectable: Used in research/clinics (e.g., 1-2 mg subcutaneous doses for hair/wounds). Not FDA-approved for most uses—consult a doctor.
DIY/Supplements: Available as powder (e.g., 100 mg vials). Reconstitute with bacteriostatic water; typical dose 1-5 mg/day subQ or topical.
Stability: pH-sensitive (best 5-7); store cool/dark. Avoid mixing with strong acids/vitamin C (can displace Cu).

Safety and Side Effects

Generally Safe: Low toxicity (LD50 >2g/kg in rats). Topical use rarely causes irritation.
Risks:
- Excess copper: Nausea, headaches (rare at cosmetic doses).
- Allergic reactions: Histamine release possible.
- Pregnancy/Breastfeeding: Avoid due to lack of data.
Interactions: May enhance antibiotics; monitor copper levels if using long-term.
Regulation: Cosmetic-grade OK; pharma-grade for injections. Not a drug—results vary.

Comparison to Similar Peptides

Peptide	Key Difference	Best For
GHK-Cu	Copper-bound; broad regenerative.	Skin/hair repair.
GHK (no Cu)	Less potent; needs Cu for full effect.	Basic remodeling.
Matrixyl (Pal-KTTKS)	Collagen-focused, no metal.	Wrinkles only.
Argireline	Botox-like, neuromuscular.	Expression lines.

For best results, combine with sunscreen/moisturizers. Research is promising but ongoing—human trials are limited for non-cosmetic uses. If you’re using it therapeutically, get bloodwork for copper/zinc balance. Sources: Pickart’s site (copperpeptides.com), clinicaltrials.gov.

Additional information

Quantity	50mg, 100mg

Delivery Details

2-3 days from the time of purchase to all locations

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