Buy Oxymetholone, commonly known by brand names like Anadrol or Anapolon, is a synthetic anabolic-androgenic steroid (AAS) derived from dihydrotestosterone (DHT). It was first developed in the 1960s by Syntex Laboratories and is medically classified as an androgen and anabolic steroid (AAS).

Chemical and Pharmacological Facts

• Chemical Formula: C₂₁H₃₂O₃
• Molecular Weight: 332.48 g/mol
• Structure: It’s a 17α-alkylated steroid, which allows it to survive oral administration by resisting first-pass liver metabolism. This modification, however, increases hepatotoxicity.
• Mechanism of Action: Binds strongly to androgen receptors, promoting protein synthesis, nitrogen retention, and red blood cell production (erythropoiesis). It has high anabolic activity (about 3-4x that of testosterone) and moderate androgenic effects.

Evidence: Approved by the FDA in 1960 for specific uses (sources: FDA Orange Book, PubChem CID 5282334, and studies in Journal of Clinical Endocrinology & Metabolism, 1960s trials).

Medical Uses

Primarily prescribed for:

• Anemia: Treats aplastic anemia and other conditions causing red blood cell deficiency by stimulating erythropoietin production.
• Muscle-wasting diseases: Such as HIV/AIDS-related cachexia or severe burns (off-label in some cases).
• Dosage: Typically 1-5 mg/kg body weight daily for medical use, short-term (4-6 weeks) to minimize risks.

Evidence: Clinical trials (e.g., New England Journal of Medicine, 1970s) showed it increases hemoglobin levels by 1-2 g/dL in anemic patients. It’s still listed in pharmacopeias like the USP for these indications.

Non-Medical/Performance Use

Widely abused in bodybuilding and athletics for:

• Rapid muscle mass gains (up to 20-30 lbs in 4-6 weeks).
• Strength increases and improved recovery.
• Typical illicit dose: 50-150 mg/day (stacked with other steroids).

Status: Schedule III controlled substance in the US (DEA, since 1991); banned by WADA for athletes.

Side Effects and Risks

Evidence: Meta-analyses (e.g., British Journal of Pharmacology, 2010; Hepatology, 1980s case reports) link long-term use to 10-20% incidence of liver abnormalities. A 2017 study in Drug Testing & Analysis found 30-50% of users experience significant testosterone suppression post-cycle.

Detection and Half-Life

• Half-Life: 5-9 hours (active metabolites up to 15 hours).
• Detection Time: Urine (3-6 weeks), blood (2 weeks).

Legality and Availability

• Prescription-Only in most countries; illegal without Rx for performance enhancement.
• Black-market versions often counterfeit (per Forensic Science International, 2015 purity tests: ~40% fake).

Recommendation: Only use under medical supervision. PCT (post-cycle therapy) like Clomid/Nolvadex is common in abuse scenarios to restore hormones, but consult a doctor. For alternatives, consider legal supplements like creatine or natural test boosters,