5-Amino-1MQ (10mg)

Name: 5-Amino-1MQ (10mg)
SKU: 14345
Availability: InStock

$75.00

5-Amino-1MQ (10mg)

This item: 5-Amino-1MQ (10mg)

$75.00

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Reconstitution Solution (30ml) (BAC Water)

1 × Reconstitution Solution (30ml) (BAC Water)

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Description

5-Amino-1MQ (10mg)

5-Amino-1MQ (chemical name: 5-amino-1-methylquinolinium) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in metabolism. It’s gaining attention in biohacking, anti-aging, and performance optimization communities as a research chemical, often sold in 10mg capsules or vials for oral or injectable use. Note: This is not FDA-approved for human consumption—it’s strictly for research purposes. Consult a healthcare professional before any use, as human safety data is limited.

Key Potential Benefits (Based on Preclinical Studies)

Fat Loss & Metabolism: Inhibits NNMT, which may increase NAD+ levels, boost fat oxidation, and promote white-to-beige fat conversion. Animal studies (e.g., on diet-induced obese mice) show reduced body weight and fat mass without muscle loss.
Muscle Preservation: Enhances energy production in muscle cells, potentially aiding muscle endurance and recovery.
Anti-Aging & Longevity: Elevates NAD+ (similar to NMN/NR), supporting mitochondrial function, insulin sensitivity, and cellular repair.
Other: Preliminary research suggests benefits for glucose regulation, inflammation reduction, and neuroprotection.

Study Evidence	Source	Key Findings
NNMT inhibition in mice	Nature Communications (2019)	7% body weight loss, 30% fat mass reduction over 11 days; no appetite suppression.
Metabolic effects	Frontiers in Endocrinology (2022)	Improved insulin sensitivity, increased basal metabolic rate.
Human anecdotes	User reports (e.g., Reddit, Longecity)	5-15lbs fat loss in 4-8 weeks at 50-150mg/day; variable results.

Typical Dosage & Administration (Research/Community Protocols)

Standard Dose: 50-150mg/day (e.g., 1-3 x 10mg capsules), split doses. Start low (10-50mg) to assess tolerance.
Cycle: 4-12 weeks on, 4 weeks off.
Form: Oral capsules (most common for 10mg); subQ injection possible but less studied.
Stacking: Often paired with NMN (250-500mg), JBSNF-000088 (another NNMT inhibitor), or semaglutide for synergy.

Dosage Level	Frequency	Notes
Beginner	50mg/day	Single morning dose; monitor for GI upset.
Standard	100-150mg/day	Split AM/PM; with food to reduce nausea.
Advanced	200mg+/day	Rare; higher risk of side effects.

Side Effects & Risks

Common: Mild nausea, headache, fatigue (usually transient).
Rare: Elevated liver enzymes (monitor ALT/AST), insomnia if taken late.
Contraindications: Avoid with MAOIs, SSRIs, or if pregnant/breastfeeding. Long-term human data lacking—potential for unknown effects on methylation or cancer risk (NNMT linked to some tumors).
Purity: Source from reputable labs (e.g., >99% HPLC-tested); avoid unverified vendors.

Where to Buy & Cost

Research suppliers: Peptide Sciences, Orovia Biolab, Limitless Biotech, or SwissChems (~$50-100 for 10 x 10mg capsules).
Legality: Research chemical in most countries; not scheduled, but gray area for personal use.

For deeper dives, check PubMed for “5-amino-1MQ NNMT” or examine.com. Track bloodwork (NAD+, lipids, glucose) if experimenting. Stay safe! 🚀

Delivery Details

2-3 days from the time of purchase to all locations

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Research

5-Amino-1MQ Research

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small molecule belonging to the class of methylquinolinium derivatives, characterized structurally by a quinolinium core substituted with an amino group at the 5-position and a methyl group at the 1-position.

It is recognized for its potent and selective inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme implicated in a variety of metabolic and oncogenic processes.

Mechanisms of Action

5-Amino-1MQ acts predominantly by inhibiting NNMT, thereby influencing several interconnected metabolic, redox, and epigenetic pathways. NNMT plays a crucial role in the methylation of nicotinamide, affecting intracellular nicotinamide adenine dinucleotide (NAD+) metabolism—a key cellular cofactor for redox reactions, DNA repair, and transcriptional regulation.¹

In preclinical studies, treatment of mouse adipocytes with 5-Amino-1MQ resulted in a concentration-dependent increase in NAD+ levels (approximately 1.2 to 1.6-fold higher than controls), which is significant for metabolic homeostasis and cellular health.¹

Furthermore, the inhibition of NNMT by 5-Amino-1MQ impacts histone methylation, thereby modulating gene expression programs underlying metabolism and oncogenesis.²

Metabolic and Anti-Obesity Efficacy

In the context of metabolic health disorders, particularly obesity and related syndromes, 5-Amino-1MQ demonstrates remarkable efficacy.³ In diet-induced obesity mouse models, administration of 5-Amino-1MQ led to notable reductions in body weight, white adipose tissue mass, and adipocyte size, without observable adverse effects or changes in food intake.⁴

This implies its anti-obesity action does not arise from appetite suppression but rather from a direct metabolic modulation mechanism—namely, the suppression of lipogenesis (fat creation).³

These findings highlight the promise of 5-Amino-1MQ as a potential research compound for obesity and possibly type 2 diabetes.⁴

Applications in Cancer Therapy

Beyond metabolic disease, 5-Amino-1MQ has been explored extensively in preclinical oncology research. Its anticancer activity stems from two principal mechanisms: epigenetic remodeling via altered histone methylation, and direct modulation of cellular energetics and proliferation.²

Studies have shown that, in cancer-associated fibroblasts (CAFs), treatment with 5-Amino-1MQ not only modifies histone methylation patterns but also suppresses tumor-supportive metabolic functions. When applied in animal models, 5-Amino-1MQ has demonstrated the capacity to reduce tumor cell proliferation and alter the tumor microenvironment in favor of therapeutic intervention.²

These dual effects position it as a potential research candidate for both monotherapy and combination strategies in gynecological and potentially other malignancies.

Pharmacokinetics and Pharmacodynamics

While 5-Amino-1MQ exhibits strong biological activity and therapeutic promise, optimization of its pharmacokinetic and pharmacodynamic profiles remains a focus of ongoing research. Its effective cellular permeability and membrane passage have already been demonstrated, which supports its use across a variety of tissue types.³

Further in vitro studies are needed to refine aspects such as tissue-specific targeting, metabolic stability, and elimination, with the aim of maximizing clinical potential and minimizing off-target effects.

References

Conlon, N., & Ford, D. (2022). A systems-approach to NAD+ restoration.. Biochemical pharmacology, 114946 . https://doi.org/10.1016/j.bcp.2022.114946.
Myong, S., Nguyen, A., & Challa, S. (2024). Biological Functions and Therapeutic Potential of NAD+ Metabolism in Gynecological Cancers. Cancers, 16. https://doi.org/10.3390/cancers16173085.
Li, X., Pi, Y., Chen, Y., Zhu, Q., & Xia, B. (2022). Nicotinamide N-Methyltransferase: A Promising Biomarker and Target for Human Cancer Therapy. Frontiers in Oncology, 12. https://doi.org/10.3389/fonc.2022.894744.
Liu, J., Deng, Z., Zhu, X., Zeng, Y., Guan, X., & Li, J. (2021). Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes. BioMed Research International, 2021. https://doi.org/10.1155/2021/9924314.