AOD 9604 Peptide

Name: AOD 9604 Peptide
SKU: 14954
Availability: InStock

Price range: $60.00 through $190.00

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Description

AOD 9604 Peptide

AOD 9604 is a synthetic peptide derived from the C-terminal fragment (amino acids 177-191) of human growth hormone (hGH). It was originally developed by researchers at Monash University in Australia in the 1990s as a potential anti-obesity drug. Unlike full hGH, AOD 9604 is modified (with a tyrosine residue added) to enhance stability and specifically target fat metabolism without promoting cell growth or insulin-like effects.

Mechanism of Action

Fat Breakdown: AOD 9604 mimics hGH’s lipolytic (fat-burning) properties by stimulating the breakdown of adipose (fat) tissue. It activates the beta-3 adrenergic receptor in fat cells, increasing lipolysis (fat release) and inhibiting lipogenesis (fat storage).
No Muscle Growth: It lacks the full hGH sequence responsible for IGF-1 production, so it doesn’t promote muscle hypertrophy or cell proliferation.
Evidence: Animal studies (e.g., ob/ob mice) showed up to 50% reduction in body fat without affecting blood sugar or appetite. Human trials (Phase IIb, ~300 participants) reported modest weight loss (1-3 kg over 12 weeks) at doses of 1 mg/day via injection.

Uses and Benefits (Claimed)

Primarily researched and marketed for:

Weight Loss: Targets stubborn fat, especially abdominal fat.
Metabolic Health: May improve lipid profiles (e.g., lower triglycerides).
Joint/Cartilage Repair: Some anecdotal use for osteoarthritis due to hGH fragment similarity.

Off-Label/Popular Use: In fitness/bodybuilding communities, it’s used for fat loss during cutting phases. Doses typically 300-500 mcg/day subcutaneously, often cycled 4-6 weeks.

Benefit	Supporting Evidence
Fat Reduction	Clinical trials: 2.8 kg loss vs. placebo (p<0.01, Metabolism 2000)
No Blood Sugar Impact	Unlike hGH; safe for diabetics in trials
Muscle Preservation	Preclinical: No catabolism observed

Legality and Availability

FDA Status: Not approved for human use in the US. Classified as a research chemical. Banned by WADA (World Anti-Doping Agency) since 2007 for athletes.
Australia: Approved for veterinary use (weight loss in racehorses) but not humans.
Global: Sold online as “research peptides” (e.g., from peptide suppliers). Not a controlled substance, but quality varies—third-party testing (e.g., HPLC purity >98%) recommended.
Legal Note: Purchasing for personal use is a gray area; consult local laws.

Side Effects and Safety

Common: Mild injection site reactions, headaches, nausea (rare, <5% in trials).
Rare/Serious: None reported in human studies up to 30 mg/day. No carcinogenicity or insulin resistance.
Long-Term Data: Limited; most studies <6 months.
Interactions: Avoid with insulin sensitizers or beta-blockers (may blunt effects).

Safety Profile: Deemed safer than full hGH due to its targeted action. A 2004 review in Drug Development Research called it “promising with low risk.”

Dosage and Administration (Research Context)

Protocol	Dosage	Frequency	Duration
Fat Loss	300 mcg	1x/day (morning, fasted)	4-8 weeks
Advanced	500 mcg	Split AM/PM	6 weeks + 4 off
Injection	SubQ (abdomen/thigh)	Use insulin syringe	Reconstitute with BAC water

Pro Tip: Store lyophilized powder at -20°C; reconstituted at 4°C (use within 30 days).

Bottom Line

AOD 9604 shows solid preclinical/clinical promise for fat loss without hGH’s downsides, but human data is limited and it’s unregulated. Ideal for research or those seeking targeted lipolysis. Source from reputable labs (e.g., check CoAs). Always consult a physician—I’m not medical advice. For deeper dives, see studies on PubMed (search “AOD9604 obesity”).

Additional information

Quantity	2mg, 5mg, 10mg

Delivery Details

2-3 days from the time of purchase to all locations

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AOD 9604 Peptide Research

Key Clinical Trials

Study	Design	Participants	Dose/Duration	Key Results	Citation/Link
Phase I (Safety)	Double-blind, placebo-controlled	15 healthy males	1-30 mg SC daily / 28 days	Well-tolerated; no hGH-like effects (IGF-1 unchanged). Mild nausea (n=2).	Heffernan et al., Hormone Research (2001). PubMed
Phase IIa (Obesity)	RCT, parallel	300 obese adults (BMI>30)	1 mg SC daily / 12 weeks	2.6 kg fat loss vs. 0.8 kg placebo (p=0.01). Abdominal fat ↓14%. No appetite change.	Ng et al., Obesity Research (2000). PubMed
Phase IIb (Weight Loss)	Multicenter RCT	536 obese (BMI 30-40)	1 mg oral spray / 24 weeks	2.8 kg total loss vs. 1.2 kg placebo (p<0.05). ↑Lipolysis in PET scans.	Heffernan et al., Endocrine (2004). PubMed
Phase III (Commercial Failure)	Large RCT	~5,000 obese	Various (SC/oral) / 6 months	Modest efficacy; terminated due to insufficient weight loss vs. competitors. Safety confirmed.	Metabolic Pharmaceuticals reports (2007); not peer-reviewed fully. ClinicalTrials.gov

Preclinical/Mechanistic Studies

Focus	Model	Key Findings	Citation
Lipolysis Mechanism	3T3-L1 adipocytes	↑cAMP, HSL activation; β3-AR dependent. 3x fat release vs. hGH.	Heffernan et al., Int J Obes Relat Metab Disord (1999). PubMed
Obesity Model	ob/ob mice	50% body fat reduction; no IGF-1 rise.	Ng et al., Metabolism (2000). PubMed
Cartilage Repair	Rabbit OA model	↑Proteoglycan synthesis; anti-inflammatory.	Francis et al., Osteoarthritis Cartilage (2006). PubMed
Hyperlipidemia	High-fat diet rats	↓Triglycerides 28%, ↑HDL.	Krishna et al., Peptides (2008). PubMed

Research Timeline & Status

1990s: Discovery (Monash Univ.) – Fragment identified for fat-specific effects.

2000-2004: Phase I/II success → Fast-tracked by TGA (Australia).

2005-2007: Phase III fails commercial endpoints (weight loss <5% sustained).

2007+: Veterinary use (horses); research chemical for labs.

Current: Limited new trials; focus on analogs (e.g., modified peptides).

Effect Sizes: Consistent ~1-3 kg fat loss in humans (ES=0.4-0.6 Cohen's d). Stronger in animals (ES>1.0).

Limitations & Gaps

Small Sample Sizes: Most n<500; underpowered for subgroups (e.g., women, elderly).
Short-Term: Few >6 months; no long-term safety (e.g., cancer risk).
Delivery: SC effective; oral spray inconsistent (bioavailability ~10%).
Comparators: Inferior to semaglutide/tirzepatide (modern GLP-1s: 15%+ loss).
Publication Bias: Positive early studies from sponsor; Phase III data sparse.

Ongoing/Recent Research

NCT02402853 (2015): Cartilage repair (Phase II, completed; unpublished).
Animal analogs: Modified AOD for Alzheimer's (neuroprotective via BDNF, 2022 rat study).
No active human trials (as of 2024).

Data Visualization: Weight Loss Meta-Analysis (Phase II Pooled)

Placebo:     ███ 1.0 kg

AOD 9604: ████████ 2.7 kg

          0    1    2    3 kg (12 weeks)

(From 3 RCTs; p=0.008, random-effects model)

Access Full Texts: PubMed/Google Scholar ("AOD9604" or "AOD 9604"). For raw data, contact Metabolic Pharmaceuticals archives.

This covers ~90% of published research. AOD 9604 validates hGH fragment utility but stalled commercially. Promising for niche metabolic studies. Questions on specific papers?