Ipamorelin is a synthetic peptide analog of growth hormone-releasing hormone (GHRH). It’s a selective ghrelin receptor agonist (also known as a growth hormone secretagogue) that stimulates the pituitary gland to release growth hormone (GH) without significantly affecting cortisol or prolactin levels—unlike some other peptides like GHRP-6. A 10mg vial is a common concentration for research or compounding purposes.

Key Properties

Common Uses (Research/Off-Label)

• Anti-Aging & Recovery: Promotes GH/IGF-1 elevation for muscle repair, fat loss, and skin elasticity.
• Bodybuilding/Fitness: Enhances lean mass gains, joint health, and sleep quality when stacked with CJC-1295 (no DAC).
• Clinical Research: Studied for GH deficiency, osteoporosis, and wound healing.
• Not FDA-Approved: Sold as a research chemical; human use is unregulated and carries risks.

Reconstitution & Dosing Guidelines (For Research)

Ipamorelin is typically lyophilized (freeze-dried) in 10mg vials. Reconstitute with bacteriostatic water (bac water).

1. Reconstitution:

• Draw air into syringe equal to water volume.
• Inject air into vial, then slowly add bac water along vial wall (avoid foaming).
• Gently swirl; store refrigerated (stable 4–6 weeks).

2. Typical Research Doses:

• Injection Sites: Abdomen, thigh (rotate to avoid irritation).
• Start low to assess tolerance.

Storage

• Unreconstituted: Room temp or freezer (2+ years shelf life).
• Reconstituted: Refrigerator (2–8°C); discard if cloudy/particles form.

Potential Side Effects (Dose-Dependent)

• Mild: Head rush, water retention, numbness in extremities.
• Rare: Increased hunger (less than GHRPs), injection site reactions.
• Monitor: Bloodwork for IGF-1, glucose (can lower insulin sensitivity long-term).

Evidence & Studies

• Key Research: A 1998 study in Endocrinology showed Ipamorelin dose-dependently increases GH in pigs/humans without cortisol spike (Raun et al.).
• Human Trials: Limited; Phase II for post-op ileus showed safety up to 100mcg/kg (Hansen et al., 2001).
• GH benefits backed by meta-analyses (e.g., Liu et al., 2007 in Annals of Internal Medicine): +2–4kg lean mass, -2kg fat over 6 months.

Disclaimer: This is for informational/research purposes only. Ipamorelin is not approved for human therapeutic use by FDA/EMA. Consult a physician; self-administration carries legal/health risks. Sourcing from reputable labs (e.g., >99% HPLC-tested) is critical to avoid contaminants.